Endoscopy
Endoscopy

After several decades of technology and application development, endoscopy has been established as an indispensable diagnostic tool for a variety of internal medicine fields. However, it is still based on color imaging offering low contrast and color patterns non-specific to the underlying pathologies.

Early stage lesions often escape the attention of the examiner or are perceived with low contrast, raising diagnostic uncertainties. The direct consequence of these inefficiencies is multiple and often randomly selected biopsies.

After several decades of technology and application development, endoscopy has been established as an indispensable diagnostic tool for a variety of internal medicine fields. However, it is still based on color imaging offering low contrast and color patterns non-specific to the underlying pathologies.

Early stage lesions often escape the attention of the examiner or are perceived with low contrast, raising diagnostic uncertainties. The direct consequence of these inefficiencies is multiple and often randomly selected biopsies.

There is therefore a clear and unmet demand for imaging technologies, adaptable to endoscopy, that will help physicians and surgeons see the chemistry behind the colors and to inform them instantly about early signs of disease. QCELL addresses this demand with a proprietary imaging technology: The Spectral Artificial Intelligence Examination (SAVE) endoscopy technology.

There is therefore a clear and unmet demand for imaging technologies, adaptable to endoscopy, that will help physicians and surgeons see the chemistry behind the colors and to inform them instantly about early signs of disease. QCELL addresses this demand with a proprietary imaging technology: The Spectral Artificial Intelligence Examination (SAVE) endoscopy technology.

SAVE Endoscope
SAVE Endoscope

SAVE is an advanced, multimodal, multichannel digital system, which adapts to all kinds of rigid endoscopes (ENT, Gyn, ourology, orthopedics etc.) and establishes spectral patterns to a wide spectrum of diseases. Multimodal spectral vision offers sufficient contrast and establishes spectral patterns and signatures for a wide spectrum of tissue lesions, thus improving diagnostic outcomes while minimizing the need for biopsies.

SAVE is an advanced, multimodal, multichannel digital system, which adapts to all kinds of rigid endoscopes (ENT, Gyn, ourology, orthopedics etc.) and establishes spectral patterns to a wide spectrum of diseases. Multimodal spectral vision offers sufficient contrast and establishes spectral patterns and signatures for a wide spectrum of tissue lesions, thus improving diagnostic outcomes while minimizing the need for biopsies.

Clinical Value & Utility
Clinical Value & Utility

The SAVE system adapts to any rigid endoscope, converting it to a powerful instrument assisting in vivo diagnosis. SAVE endoscope has been extensively used as an investigational device by several Universities and Research Centers, indicatively:

In an on going clinical study, SAVE endoscope is used to establish the spectral patterns of various endometrial pathologies, often comprising the grounds of infertility.

Infertility has many causes. Finding “what is going on” is a real challenge. It is an expensive and invasive process: 38% of women with infertility have uterine cavity abnormalities. Conventional Hysteroscopy is a subjective process and needs biopsies for definitive diagnosis. Biopsies may cause scarring, degrading the quality of the epithelium.

It is time for a change.

The SAVE system adapts to any rigid endoscope, converting it to a powerful instrument assisting in vivo diagnosis. SAVE endoscope has been extensively used as an investigational device by several Universities and Research Centers, indicatively:

In an on going clinical study, SAVE endoscope is used to establish the spectral patterns of various endometrial pathologies, often comprising the grounds of infertility.

Infertility has many causes. Finding “what is going on” is a real challenge. It is an expensive and invasive process: 38% of women with infertility have uterine cavity abnormalities. Conventional Hysteroscopy is a subjective process and needs biopsies for definitive diagnosis. Biopsies may cause scarring, degrading the quality of the epithelium.

It is time for a change.

HD colour image (left) and spectral mapping of the endometrium (right) revealing classes with different spectral profiles with pseudo-colours, in real-time.

SAVE hysteroscopy has shown great potential for:

  • Detecting and mapping endometrial pathologies – the grounds of infertility
  • Reducing the number of biopsies
  • Guiding the implantation of fertilized eggs at the right time widow and tissue area
  • Reducing multiple and ectopic pregnancies

SAVE hysteroscopy has shown great potential for:

  • Detecting and mapping endometrial pathologies – the grounds of infertility
  • Reducing the number of biopsies
  • Guiding the implantation of fertilized eggs at the right time widow and tissue area
  • Reducing multiple and ectopic pregnancies
SAVE Technology & Specifications
SAVE Technology & Specifications

The SAVE system acquires and displays color, spectral images and spectral mapping images, all at video rates. The spectral mapping image is a comprehensive representation  of the spectral information content of an acquired spectral cube. More specifically, the millions of spectra contained in the spectral cubes are automatically grouped together in classes using spectral similarity criteria.

Spectral classes are visualized using artificial color-coding, with each spectral cluster representing image areas with similar spectral characteristics. Altered spectral profiles often reflect altered biochemistry and/or structure caused by a pathology. Moreover, since light penetration into tissue is a wavelength dependent property, blue-ultraviolet spectral images depict fine surface features, while infrared images display invisible subsurface features.

The SAVE system acquires and displays color, spectral images and spectral mapping images, all at video rates. The spectral mapping image is a comprehensive representation  of the spectral information content of an acquired spectral cube. More specifically, the millions of spectra contained in the spectral cubes are automatically grouped together in classes using spectral similarity criteria.

Spectral classes are visualized using artificial color-coding, with each spectral cluster representing image areas with similar spectral characteristics. Altered spectral profiles often reflect altered biochemistry and/or structure caused by a pathology. Moreover, since light penetration into tissue is a wavelength dependent property, blue-ultraviolet spectral images depict fine surface features, while infrared images display invisible subsurface features.

Multimodal-Multichannel imaging modalities by SAVE endoscopy: color (a), narrow-band imaging enchanting visualization of atypical vessels (b), fluorescence imaging of ALA  (c ), spectral mapping (d), Infrared imaging revealing sub-surface features (e) longer wavelength infrared imaging revealing deeper features (f)

Specifications

  • 6 megapixels color and spectral imaging supporting visualization on extra large screens
  • Video rate color and near infrared spectral imaging side-by-side displayed
  • Video rate spectral mapping and spectral classification
  • Spectrum per pixel
  • High power multichannel LED illumination-no heating effects.
  • Multichannel fluorescence excitation for both endogenous and exogenous fluorophore spectral mapping.
  • Spectral chromoendoscopy allowing for the separated mapping of multiple contrast agents
  • Endocytoscopy and Cytospectroscopy (with contact endoscopy)

Specifications

  • 6 megapixels color and spectral imaging supporting visualization on extra large screens
  • Video rate color and near infrared spectral imaging side-by-side displayed
  • Video rate spectral mapping and spectral classification
  • Spectrum per pixel
  • High power multichannel LED illumination-no heating effects.
  • Multichannel fluorescence excitation for both endogenous and exogenous fluorophore spectral mapping.
  • Spectral chromoendoscopy allowing for the separated mapping of multiple contrast agents
  • Endocytoscopy and Cytospectroscopy (with contact endoscopy)